Lewis acid free synthesis of 3,4-dihydro-1H-indazolo[1,2-b]phthalazine-1,6,11(2H,13H)-triones promoted by 1,1,1,3,3,3-hexafluoro-2-propanol

被引：60

作者：

Maleki, Behrooz ^{[1
]}

Ashrafi, Samaneh Sedigh ^{[1
]}

Tayebee, Reza ^{[1
]}

机构：

[1] Hakim Sabzevari Univ, Dept Chem, Sabzevar 9617976487, Iran

来源：

RSC ADVANCES | 2014年 / 4卷 / 78期

关键词：

ONE-POT SYNTHESIS; EFFICIENT CATALYST; 3-COMPONENT SYNTHESIS; FLUORINATED ALCOHOLS; POLYMERIC CATALYST; METAL-FREE; DERIVATIVES; PHTHALAZINE; OXIDATION;

D O I：

10.1039/c4ra06768a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A convenient, environmentally friendly and efficient procedure for the synthesis 3,4-dihydro-1H-indazolo[1,2-b]phthalazine-1,6,11(2H,13H)-trione derivatives has been developed via multi-component and one-pot reactions of various aldehydes with cyclic 1,3-diketones and phthalhydrazide 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP). In simple and mild reaction conditions, the use of HFIP is explored as an easy workup and a green catalyst for the one-pot three-component synthesis of 3,4-dihydro-1H-indazolo[1,2-b]phthalazine-1,6,11(2H, 13H)-triones. Thus, this practical method is developed as a notable medium for these derivatives via a multicomponent reaction.

引用

页码：41521 / 41528

页数：8

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