Soy flour-ZnO nanoparticles for controlled release of silibinin: Effect of ZnO nanoparticle, surfactant, and cross-linker

被引：3

作者：

Gogoi, Plabita ^{[1
]}

Das, Monoj K. ^{[1
]}

Ramteke, Anand ^{[1
]}

Maji, Tarun Kumar ^{[1
]}

机构：

[1] Tezpur Univ, Dept Chem Sci, Napaam 784028, Assam, India

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2018年 / 67卷 / 09期

关键词：

Genipin; silibinin; soy flour; IRON-OXIDE NANOPARTICLES; IN-VITRO; CHITOSAN MICROSPHERES; CELL PROLIFERATION; DELIVERY; GENIPIN; CANCER; NANOCLAY; PROTEIN; GROWTH;

D O I：

10.1080/00914037.2017.1354200

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Silibinin-loaded soy flour-zinc oxide nanoparticle (ZnO) nanoparticles were prepared and characterized by different techniques. The average particle size and zeta potential value of the nanoparticles were found in the range 10-15nm and -29.88 to -40.85mV, respectively. The effects of ZnO nanoparticle, surfactant, and cross-linker were evaluated with regard to swelling, encapsulation efficiency, and drug release in different pH medium. Both swelling degree (%) and cumulative release (%) were better in pH 7.4 and maximum cumulative release (%) was 50%. Cytotoxicity study was performed by MTT assay using normal human blood and MDA-MB-435S cancer cell lines. [GRAPHICS]

引用

页码：543 / 552

页数：10