The epithelial cell cytoskeleton and intracellular trafficking - III. How is villin involved in the actin cytoskeleton dynamics in intestinal cells?

被引：49
|
作者：
Athman, R [1 ]
Louvard, D [1 ]
Robine, S [1 ]
机构：
[1] Inst Curie, UMR 144, Lab Morphogenese & Signalisat Cellulaires, F-75248 Paris 5, France
来源：
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2002年 / 283卷 / 03期
关键词：
F-actin; gelsolin family; cell motility; Shigella infection;
D O I：
10.1152/ajpgi.00207.2002
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Villin plays a key role in the maintenance of the brush border organization by bundling F-actin into a network of parallel filaments. Our previous in vivo data on villin knockout mice showed that, although this protein is not necessary for the bundling of F-actin, it is important for the reorganization of the actin cytoskeleton elicited by stress conditions. We further investigated villin property to initiate actin remodeling in cellular processes such as hepatocyte growth factor-induced motility, morphogenesis, and bacterial infection. Our data suggest that villin is involved in actin remodeling necessary for many cellular processes requiring the actin cytoskeleton plasticity.
引用
收藏
页码：G496 / G502
页数：7
相关论文
共 45 条
  • [1] The epithelial cell cytoskeleton and intracellular trafficking - II. Intestinal epithelial cell exosomes: perspectives on their structure and function
    van Niel, G
    Heyman, M
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2002, 283 (02): : G251 - G255
  • [2] Apical Invasion of Intestinal Epithelial Cells by Salmonella typhimurium Requires Villin to Remodel the Brush Border Actin Cytoskeleton
    Lhocine, Nouara
    Arena, Ellen T.
    Bomme, Perrine
    Ubelmann, Florent
    Prevost, Marie-Christine
    Robine, Sylvie
    Sansonetti, Philippe J.
    [J]. CELL HOST & MICROBE, 2015, 17 (02) : 164 - 177
  • [3] The RUFYs, a Family of Effector Proteins Involved in Intracellular Trafficking and Cytoskeleton Dynamics
    Char, Remy
    Pierre, Philippe
    [J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, 8
  • [4] Desmosome dynamics in migrating epithelial cells requires the actin cytoskeleton
    Roberts, Brett J.
    Pashaj, Anjeza
    Johnson, Keith R.
    Wahl, James K., III
    [J]. EXPERIMENTAL CELL RESEARCH, 2011, 317 (20) : 2814 - 2822
  • [5] Epithelial cell cytoskeleton and intracellular trafficking - V. Confluence of membrane trafficking and motility in epithelial cell models
    Casanova, JE
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2002, 283 (05): : G1015 - G1019
  • [6] Villin enhances hepatocyte growth factor-induced actin cytoskeleton remodeling in epithelial cells
    Louvard, RAD
    Robine, S
    [J]. MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (11) : 4641 - 4653
  • [7] Actin cytoskeleton controls movement of intracellular organelles in pancreatic duct epithelial cells
    Jung, Seung-Ryoung
    Seo, Jong Bae
    Shim, Donghwan
    Hille, Bertil
    Koh, Duk-Su
    [J]. CELL CALCIUM, 2012, 51 (06) : 459 - 469
  • [8] The epithelial cell cytoskeleton and intracellular trafficking - V. Polarized compartmentalization of antigen processing and Toll-like receptor signaling in intestinal epithelial cells
    Hershberg, RM
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2002, 283 (04): : G833 - G839
  • [9] Serotonin modifies actin cytoskeleton in human intestinal epithelial cells via involvement of PKCα
    Gill, Ravinder
    Turner, Jerrold
    Saksena, Seema
    Alrefai, Waddah
    Annaba, Fadi
    Pant, Nitika
    Ramaswamy, Krishnamurthy
    Dudeja, Pradeep
    [J]. FASEB JOURNAL, 2007, 21 (05): : A588 - A588
  • [10] Cell biology of the movement of breast cancer cells: Intracellular signalling and the actin cytoskeleton
    Jiang, Ping
    Enomoto, Atsushi
    Takahashi, Masahide
    [J]. CANCER LETTERS, 2009, 284 (02) : 122 - 130
12345