Causes and Pathophysiology of Heart Failure with Preserved Ejection Fraction

被引：23
|
作者：
Kovacs, Arpad [1 ]
Papp, Zoltan [1 ]
Nagy, Laszlo [1 ]
机构：
[1] Univ Debrecen, Inst Cardiol, Fac Med, Div Clin Physiol, H-4032 Debrecen, Hungary
来源：
HEART FAILURE CLINICS | 2014年 / 10卷 / 03期
基金：
匈牙利科学研究基金会;
关键词：
Heart failure with preserved ejection fraction; Ventricular-arterial uncoupling; Exercise intolerance; Comorbidities; Myocardial stiffness; LATE SODIUM CURRENT; DIASTOLIC DYSFUNCTION; ARTERIAL STIFFNESS; LEFT-VENTRICLE; HYPERTROPHIC CARDIOMYOPATHY; ENDOTHELIAL DYSFUNCTION; MYOCARDIAL FIBROSIS; PASSIVE STIFFNESS; ACTIVE RELAXATION; CARDIAC STRUCTURE;
D O I：
10.1016/j.hfc.2014.04.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Heart failure with preserved ejection fraction (HFPEF) is frequently associated with multiple disorders complicating both the clinical management and the understanding of the underlying mechanisms. This review focuses on the causes and pathophysiology of HFPEF and overviews how cellular and molecular changes related to various comorbidities may influence the age-dependent and gender-dependent hemodynamic alterations of diastolic ventricular function.
引用
收藏
页码：389 / +
页数：11
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