DNA vaccines against mycobacterial diseases

被引：4

作者：

Romano, Marta ^{[1
]}

Huygen, Kris ^{[1
]}

机构：

[1] Sci Inst Publ Hlth Site Ukkel, Program Immunol & Vaccinol, B-1180 Brussels, Belgium

来源：

EXPERT REVIEW OF VACCINES | 2009年 / 8卷 / 09期

关键词：

Buruli ulcer; Johne's disease; paratuberculosis; postexposure DNA vaccine; prophylactic DNA vaccine; tuberculosis; AVIUM SUBSP PARATUBERCULOSIS; MYCOLYL-TRANSFERASE AG85A; T-CELL RESPONSES; PHOSPHATE-TRANSPORT RECEPTOR; PRIME-BOOST VACCINATION; BOVIS BCG VACCINATION; PROTECTIVE EFFICACY; IMMUNE-RESPONSES; BURULI ULCER; ANTIGEN; 85A;

D O I：

10.1586/ERV.09.87

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bacteria belonging to the genus Mycobacterium can cause several infectious diseases affecting humans and animals. Here, we reviewed the latest advances in the development of DNA vaccines against TB, Buruli ulcer and Johne's disease. Current understanding of the immunity to the respective causative pathogens indicates that the use of DNA vaccines encoding mycobacterial antigens could lead to efficient vaccination strategies. Moreover, characterization of protective mycobacterial antigens has been greatly facilitated by the analysis of immune responses induced after DNA vaccination. In addition, work aiming at optimizing DNA vaccines against mycobacterial diseases and research related to the controversial development of postexposure and therapeutic DNA vaccines are also discussed.

引用

页码：1237 / 1250

页数：14

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