Epigenetic remodeling in heart failure with preserved ejection fraction

被引:7
|
作者
Ambrosini, Samuele [1 ]
Gorica, Era [1 ,2 ]
Mohammed, Shafeeq A. [1 ]
Costantino, Sarah [1 ]
Ruschitzka, Frank [3 ]
Paneni, Francesco [1 ,3 ,4 ]
机构
[1] Univ Zurich, Ctr Mol Cardiol, Zurich, Switzerland
[2] Univ Pisa, Dept Pharm, Pisa, Italy
[3] Univ Heart Ctr, Cardiol, Zurich, Switzerland
[4] Univ Hosp Zurich, Dept Res & Educ, Zurich, Switzerland
关键词
biomarkers; epigenetics; heart failure with preserved ejection fraction; personalized medicine; NF-KAPPA-B; DNA METHYLATION; ADIPOSE-TISSUE; DOUBLE-BLIND; PATHOPHYSIOLOGY; ATHEROSCLEROSIS; DEACETYLATION; THERAPIES; CHROMATIN;
D O I
10.1097/HCO.0000000000000961
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of review In this review, we critically address the role of epigenetic processing and its therapeutic modulation in heart failure with preserved ejection fraction (HFpEF). Recent findings HFpEF associates with a poor prognosis and the identification of novel molecular targets and therapeutic approaches are in high demand. Emerging evidence indicates a key involvement of epigenetic signals in the regulation of transcriptional programs underpinning features of HFpEF. The growing understanding of chromatin dynamics has led to the development of selective epigenetic drugs able to reset transcriptional changes thus delaying or preventing the progression toward HFpEF. Epigenetic information in the setting of HFpEF can be employed to: (i) dissect novel epigenetic networks and chromatin marks contributing to HFpEF; (ii) unveil circulating and cell-specific epigenetic biomarkers; (iii) build predictive models by using computational epigenetics and deep machine learning; (iv) develop new chromatin modifying drugs for personalized management of HFpEF. Acquired epigenetic signatures during the lifetime can contribute to derail molecular pathways involved in HFpEF. A scrutiny investigation of the individual epigenetic landscape will offer opportunities to develop personalized epigenetic biomarkers and therapies to fight HFpEF in the decades to come.
引用
收藏
页码:219 / 226
页数:8
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