Duloxetine in Adults With ADHD: A Randomized, Placebo-Controlled Pilot Study

被引：16
|
作者：
Bilodeau, Mathieu [1 ]
Simon, Tarek [2 ]
Beauchamp, Miriam H. [3 ]
Lesperance, Paul [4 ]
Dubreucq, Simon
Doree, Jean-Pierre [5 ]
Tourjman, Smadar Valerie [6 ]
机构：
[1] Univ Montreal, Montreal, PQ H3C 3J7, Canada
[2] Univ Laval, Montreal, PQ, Canada
[3] Ste Justine Hosp Res Ctr, Montreal, PQ, Canada
[4] Ctr Hosp Univ Montreal, Montreal, PQ, Canada
[5] Ctr Hosp Pierre Legardeur, Montreal, PQ, Canada
[6] Hop Louis H Lafontaine, Ctr Rech Fernand Seguin, Montreal, PQ, Canada
来源：
JOURNAL OF ATTENTION DISORDERS | 2014年 / 18卷 / 02期
关键词：
ADHD; adult; nonstimulant; cymbalta; duloxetine; DEFICIT HYPERACTIVITY DISORDER; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; MAJOR DEPRESSIVE DISORDER; ANXIETY DISORDER; ADVERSE EVENTS; ADOLESCENTS; EFFICACY; PROFILE; STATES; SCALE;
D O I：
10.1177/1087054712443157
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
Objective: To assess the effect of duloxetine on ADHD in adults. Method: In a 6-week double-blind trial, 30 adults with ADHD received placebo or duloxetine 60 mg daily. The Conners' Adult ADHD Rating Scale (CAARS) and the Clinical Global Impression Scales (CGI) were used to assess symptom severity and clinical improvement. The Hamilton Anxiety Rating Scale (HARS) and the Hamilton Depression Rating Scale (HDRS) were used to measure the effect on anxiety and depressive symptoms. Results: The Duloxetine group showed lower score on CGI-Severity at Week 6 (3.00 vs. 4.07 for placebo, p < .001), greater improvement on CGI-Improvement (2.89 vs. 4.00 at Week 6, p < .001), and greater decreases on five of eight subscales of the CAARS. There was no treatment group effect on HDRS or HARS scores. Conclusion: Duloxetine may be a therapeutic option for adults with ADHD, but further studies are required to replicate these findings in larger samples.
引用
收藏
页码：169 / 175
页数：7
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