1H, 13C, and 15N NMR assignments of a Drosophila Hedgehog autoprocessing domain

被引：5

作者：

Xie, Jian ^{[1
]}

Du, Zhenming ^{[1
]}

Callahan, Brian ^{[2
]}

Belfort, Marlene ^{[3
]}

Wang, Chunyu ^{[1
]}

机构：

[1] Rensselaer Polytech Inst, Biochem & Biophys Grad Program, Ctr Biotechnol & Interdisciplinary Studies, Troy, NY 12180 USA

[2] SUNY Binghamton, Dept Chem, Binghamton, NY 13902 USA

[3] SUNY Albany, Dept Biol Sci, Albany, NY 12222 USA

来源：

BIOMOLECULAR NMR ASSIGNMENTS | 2014年 / 8卷 / 02期

关键词：

Assignments; Autoprocessing; Drosophila; Hedgehog; NMR; PROTEIN; MECHANISM; INTEIN;

D O I：

10.1007/s12104-013-9500-8

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The Hedgehog (Hh) signaling pathway plays important roles in embryonic growth and patterning in different organisms. Abnormal activity of the Hh signaling pathway has been associated to cancers, holoprosencephaly and autism spectrum disorders. The backbone and side chain resonance assignments of a Drosophila Hh autoprocessing domain have been determined based on triple-resonance experiments with the [C-13, N-15]-labeled and [H-2, C-13, N-15])-labeled proteins.

引用

页码：279 / 281

页数：3

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