Evaluation of a Novel Plasma (1,3)-β-D-Glucan Detection Assay for Diagnosis of Candidemia in Pediatric Patients

被引：16

作者：

Liu, Ying ^{[1
]}

Chen, Feng ^{[1
]}

Zhu, Xiaodong ^{[2
]}

Shen, Lisong ^{[1
]}

Zhang, Sean X. ^{[3
,4
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Clin Lab, Shanghai 200030, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Pediat, Shanghai 200030, Peoples R China

[3] Johns Hopkins Univ, Sch Med, Dept Pathol, Div Med Microbiol, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2015年 / 53卷 / 09期

关键词：

BLOOD-STREAM INFECTIONS; BETA-D-GLUCAN; FUNGAL-INFECTIONS; PERFORMANCE; CHILDREN;

D O I：

10.1128/JCM.00673-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We evaluated a novel plasma (1,3)-beta-D-glucan (BDG) detection assay for the diagnosis of candidemia in children. The median BDG levels were 73.4 pg/ml in patients with candidemia and <10 pg/ml in patients without candidemia (P < 0.001). Receiver operating characteristic analysis revealed a cutoff point of 14 pg/ml and an area under the curve of 0.802. At these values, the assay demonstrated 68% sensitivity, 91% specificity, 66% positive predictive value, and 91% negative predictive value. Plasma BDG levels were undetectable in 18 candidemia cases.

引用

页码：3017 / 3020

页数：4

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