MalarlmDB: an open-access literature-based malaria immunology database

被引:5
|
作者
Deroost, Katrien [1 ]
Opdenakker, Ghislain [1 ]
Van den Steen, Philippe E. [1 ]
机构
[1] Katholieke Univ Leuven, Univ Leuven, Rega Inst Med Res, Immunobiol Lab, B-3000 Leuven, Belgium
关键词
MalarlmDB; Plasmodium; blood-stage malaria; clinical studies; mouse models; cerebral malaria; MURINE CEREBRAL MALARIA; PARASITE SEQUESTRATION; NECROSIS-FACTOR; PLASMA-LEVELS; RECEPTORS; MORTALITY; CXCR3; SUSCEPTIBILITY; DETERMINES; MANAGEMENT;
D O I
10.1016/j.pt.2014.04.006
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
The Malaria Immunology Database (MalarlmDB, www.malarimdb.org) is a novel literature-based database of host mediators in blood-stage malaria. We designed this open-access online tool because intensive malaria research has resulted in a dazzling complexity of host mediators with pathogenic or protective functions. MalarlmDB allows comparisons between expression levels in humans, expression levels in murine models, and functional data from experimental treatments in mice. The database is equipped with multiple search engines to retrieve information from many published studies. The search output is visualized schematically in tables, thereby revealing similarities and disparities. Thus, the primary aim of this database is to present a clear overview of the currently available data about malaria and to simplify literature searches.
引用
收藏
页码:309 / 316
页数:8
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