Cone-isolating ON-OFF electroretinogram for studying chromatic pathways in the retina

被引:9
|
作者
Kuchenbecker, James A. [1 ]
Greenwald, Scott H. [2 ]
Neitz, Maureen [1 ]
Neitz, Jay [1 ]
机构
[1] Univ Washington, Dept Ophthalmol, Seattle, WA 98109 USA
[2] Massachusettes Eye & Ear Infirm, Boston, MA 02214 USA
关键词
WAVELENGTH-SENSITIVE CONES; SPECTRAL SENSITIVITIES; S-CONE; MACAQUE RETINA; MIDGET PATHWAY; BIPOLAR CELLS; PHOTORECEPTORS; RESPONSES; PIGMENTS; WAVE;
D O I
10.1364/JOSAA.31.00A208
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
The electroretinogram (ERG) provides information about outer retina function in both clinical and research applications. ERG components elicited by light increments and decrements can be separated using a long-flash paradigm in which periods of light ON and OFF are alternated. Here, the ON-OFF ERG is combined with a silent substitution technique to elicit responses from individual cone photoreceptor classes by modulating the intensities of three color lights between the two periods. The results focus on the short wavelength ( S) cone pathways since they are vulnerable to disease and because there are many unanswered questions about S-cone ON and OFF circuitry. (c) 2014 Optical Society of America
引用
收藏
页码:A208 / A213
页数:6
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