CSFBACE1 activity is increased in CJD and Alzheimer disease other dementias

被引：63
|
作者：
Holsinger, R. M. D.
Lee, J. S.
Boyd, A.
Masters, C. L.
Collins, S. J.
机构：
[1] Univ Melbourne, Parkville, Vic 3052, Australia
[2] Mental Hlth Res Inst, Parkville, Vic, Australia
[3] Australian Natl Creutzfeldt Jakob Dis Registry, Melbourne, Vic, Australia
来源：
NEUROLOGY | 2006年 / 67卷 / 04期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1212/01.wnl.0000229925.52203.4c
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
To assess the diagnostic utility of CSF BACE1 activity for discriminating Alzheimer disease ( AD) from other dementias, particularly Creutzfeldt-Jakob disease (CJD), the authors studied 26 patients with sporadic CJD, 21 patients with AD, and 21 patients with various non-AD, non-CJD dementias (DCs). CSF BACE1 activity was elevated in AD in comparison with DC (p = 0.01). Unexpectedly, CSF BACE1 activity was also increased in sporadic CJD (p = 0.02).
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页码：710 / 712
页数：3
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