5-Cyanoacetylpyrimidines as intermediates for 7-aryl-6-cyanopyrido[2,3-d]pyrimidin-5-ones

被引：14

作者：

Quiroga, Jairo ^{[1
]}

Trilleras, Jorge ^{[2
]}

Galvez, Jaime ^{[1
]}

Insuasty, Braulio ^{[1
]}

Abonia, Rodrigo ^{[1
]}

Nogueras, Manuel ^{[3
]}

Cobo, Justo ^{[3
]}

机构：

[1] Univ Valle, Dept Chem, Grp Invest Compuestos Heterocicl, Cali 25360, Colombia

[2] Univ Atlantico, Programa Quim, Grp Invest Compuestos Heterocicl, Barranquilla, Colombia

[3] Univ Jaen, Dept Inorgan & Organ Chem, Jaen 23071, Spain

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 46期

关键词：

Pyrimidin-5-yl-3-oxopropanenitriles; N-(Pyrimidin-4-yl)-2-cyanoacetamides; Pyrido[2,3-d]pyrimidin-2,4,5-triones; Cyclocondensation; ONE-POT SYNTHESIS; REGIOSELECTIVE SYNTHESIS; 3-COMPONENT SYNTHESIS; CYANOACETIC ACID; IN-VITRO; DERIVATIVES; FACILE; ANTIFUNGAL; UTILITY;

D O I：

10.1016/j.tetlet.2009.08.070

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reactions of N-4- and 5-cyanoacetyl derivates of 4-aminopyrimidines with aromatic aldehydes have yielded the N-(pyrimidin-4-yl)-3-arylacrylamides and the dihydropyrido[2,3-d]pyrimidines, respectively. The first reaction was a Claisen-Schmidt reaction catalysed by base, and the second one proceeded via thermal cyclocondensation. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：6404 / 6406

页数：3

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