Tumor Necrosis Factor-Like Weak Inducer of Apoptosis and Selected Cytokines-Potential Biomarkers in Children with Solitary Functioning Kidney

被引:2
|
作者
Nosek, Hanna [1 ]
Jankowska, Dorota [2 ]
Brzozowska, Karolina [3 ]
Kazberuk, Katarzyna [3 ]
Wasilewska, Anna [3 ]
Taranta-Janusz, Katarzyna [3 ]
机构
[1] Univ Warmia & Mazury, Dept Pediat Gastroenterol & Nutr, PL-10719 Olsztyn, Poland
[2] Med Univ Bialystok, Dept Stat & Med Informat, PL-15295 Bialystok, Poland
[3] Med Univ Bialystok, Dept Paediat & Nephrol, Kilinskiego 1 St, PL-15089 Bialystok, Poland
关键词
chronic kidney disease; cytokines; solitary functioning kidney; tumor necrosis factor-like weak inducer of apoptosis;
D O I
10.3390/jcm10030497
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This study was performed to explore serum tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its dependent cytokines urinary excretion: monocyte chemoattractant protein-1 (MCP-1) and regulated on activation, normal T cell expressed and secreted chemokine (RANTES) with their relation to the kidney function parameters in children with solitary functioning kidney (SFK). The study included 80 children and adolescents (median age 9.75 year) with congenital and acquired (after surgical removal) SFK. Serum TWEAK and urinary MCP-1 and RANTES levels were significantly higher in SFK patients (p < 0.05). The serum TWEAK was positively related to serum creatinine (r = 0.356; p < 0.001). Moreover, in SFK the receiver operating characteristic analyses revealed good diagnostic profile for serum TWEAK with AUC (Area Under The Curve)-0.853, uRANTES-0.757, and for RANTES/cr.: AUC-0.816. Analysis carried out to identify children with impaired renal function (albuminuria and/or decreased estimated glomerular filtration rate < 90 mL/min/1.73 m(2) and/or hypertension) showed good profile for TWEAK (AUC-0.79) and quite good profile for uRANTES and RANTES/cr. (AUC 0.66 and 0.631, respectively). This is the first study investigating serum TWEAK and urinary excretion of MCP-1 and RANTES together in children with SFK. Obtained results indicate that TWEAK and RANTES may serve as potential markers of renal impairment.
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页码:1 / 14
页数:14
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