Utilizing on- and off-line monitoring tools to follow a kinetic resolution step during flow synthesis

被引：10

作者：

Farley, Kathleen A. ^{[1
]}

Reilly, Usa ^{[1
]}

Anderson, Dennis P. ^{[1
]}

Boscoe, Brian P. ^{[1
]}

Bundesmann, Mark W. ^{[1
]}

Foley, David A. ^{[1
]}

Lall, Manjinder S. ^{[1
]}

Li, Chao ^{[1
]}

Reese, Matthew R. ^{[1
]}

Yan, Jiangli ^{[1
]}

机构：

[1] Pfizer Worldwide Res & Dev, Med Sci, 224 Eastern Point Rd,MS 8220-4448, Groton, CT 06340 USA

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 2017年 / 55卷 / 04期

关键词：

flow NMR; flow IR; reaction monitoring; H-1; NMR; flow synthesis; enzyme; kinetic resolution; SPECTROSCOPY; NMR; ONLINE; PARAMETERS; DESIGN; TUBE;

D O I：

10.1002/mrc.4494

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In situ reaction monitoring tools offer the ability to track the progress of a synthetic reaction in real time to facilitate reaction optimization and provide kinetic/mechanistic insight. Herein, we report the utilization of flow NMR, flow IR, and other off-line spectroscopy tools to monitor the progress of a flow chemistry reaction. The on-line and off-line tools were selected to facilitate the stereoselective kinetic resolution of a key racemic monomer, which lacked a chromophore, making conventional reaction monitoring difficult. Copyright (C) 2016 John Wiley & Sons, Ltd.

引用

页码：348 / 354

页数：7

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