Highly Regioselective Synthesis of 2-Acylindolines through Cobalt-Catalyzed C-H Activation/[3+2] Annulation of Aniline Derivatives and Acrylates

被引：3

作者：

Tian, Xun ^{[1
]}

Pan, Ailin ^{[1
]}

Du, Ya ^{[1
]}

Zhang, Lening ^{[1
]}

Qin, Cuirong ^{[1
]}

Duan, Shengzu ^{[1
]}

Yang, Lijuan ^{[2
]}

Yang, Xiaodong ^{[1
]}

机构：

[1] Yunnan Univ, Yunnan Prov Ctr Res & Dev Nat Prod, Sch Pharm, Key Lab Med Chem Nat Resource,Minist Educ, Kunming 650500, Peoples R China

[2] Yunnan Minzu Univ, Sch Chem & Environm, Kunming 650500, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 24期

基金：

国家重点研发计划;

关键词：

Highly regioselective; 2-Acylindolines; Cobalt-catalysis; C-H activation; 3+2] annulation; ACTIVATION/OXIDATIVE CYCLIZATION; INDOLINES; INDOLES; DIFUNCTIONALIZATION; TEMPERATURE; AMINATION; ACID;

D O I：

10.1002/adsc.202200965

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An approach for 2-acyl indolines synthesis through Cobalt-catalyzed C-H activation/[3+2] annulation of aniline derivatives and acrylates is described. The method employs cobalt catalyst to afford a wide variety of functionalized 2-acylindolines with high regioselectivity. The mechanism is investigated by KIE experiments and deuterium-labeling experiment. The gram-scale synthesis and synthetic transformations are also conducted, confirming the scalability and application value.

引用

页码：4421 / 4426

页数：6

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