Polymorphism of angiotensinogen II T174M gene and cardiovascular diseases in the Moscow population

Groups of patients with myocardial infarction (MI) and left ventricular hypertrophy (LVH) (n = 45 and n = 53, respectively) and a sample of healthy individuals from the Moscow population (n = 60) were examined for T174M polymorphism of AGT gene (replacement of methionine for threonine at position 174 of the correspondent amino acid sequence). In MI patients, the content of TT genotypes and T allele was significantly lower than in the control group (57.8 vs. 80% and 67.9 vs. 89.2%, respectively), whereas the proportion of M allele and TM heterozygotes was increased (32.1 vs. 10.8% and 37.8 vs. 18.3%, respectively). In patients with LVH, the proportion of TT genotype (64.2%) and T allele (77.4%) was also lower than in the control group, whereas the frequency of M allele was increased (22.6%). Our results suggest that the T174M polymorphism of AGT gene is associated with MI and LVH in the Moscow population.