A Gain-Of-Function Mutation in Cardiac Myosin Binding Protein-C Increases Viscoelastic Load and Slows Shortening Velocity in Myocytes from Transgenic Mice

被引:0
|
作者
Bezold, Kristina L. [1 ]
Khosa, Jaskiran K. [2 ]
Harris, Samantha P. [2 ]
机构
[1] Univ Calif Davis, Davis, CA 95616 USA
[2] Univ Arizona, Tucson, AZ USA
关键词
D O I
10.1016/j.bpj.2013.11.1973
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
引用
收藏
页码:346A / 346A
页数:1
相关论文
共 12 条
  • [1] A Gain-of-Function Mutation in Cardiac Myosin Binding Protein-C Increases Viscoelastic Load and Slows Shortening Velocity in Myocytes from Transgenic Mice
    Bezold, Kristina L.
    Khosa, Jaskiran K.
    Harris, Samantha P.
    CIRCULATION RESEARCH, 2014, 115
  • [2] A Gain-of-Function Mutation in the M-domain of Cardiac Myosin-binding Protein-C Increases Binding to Actin
    Bezold, Kristina L.
    Shaffer, Justin F.
    Khosa, Jaskiran K.
    Hoye, Elaine R.
    Harris, Samantha P.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (30) : 21496 - 21505
  • [3] Myosin binding protein-C modulates loaded sarcomere shortening in rodent permeabilized cardiac myocytes
    Mcdonald, Kerry S.
    Kalogeris, Theodore J.
    Veteto, Adam B.
    Davis, Daniel J.
    Hanft, Laurin M.
    JOURNAL OF GENERAL PHYSIOLOGY, 2025, 157 (03):
  • [4] Loaded sarcomere shortening in permeabilized cardiac myocytes: Role of cardiac myosin binding protein-C (cMyBP-C)
    McDonald, Kerry S.
    Kalogeris, Theodore J.
    Veteto, Adam B.
    Davis, Daniel J.
    Hanft, Laurin M.
    BIOPHYSICAL JOURNAL, 2024, 123 (03) : 124A - 124A
  • [5] Cardiac Myosin Binding Protein-C Slows Cross-Bridge Kinetics and Increases MgATP Sensitivity
    Tanner, Bertrand C. W.
    Wang, Yuan
    Robbins, Jeffrey
    Palmer, Bradley M.
    BIOPHYSICAL JOURNAL, 2012, 102 (03) : 435A - 435A
  • [6] The structure of isolated cardiac myosin thick filaments from cardiac myosin binding protein-C knockout mice
    Kensler, Robert W.
    Harrist, Samantha P.
    BIOPHYSICAL JOURNAL, 2008, 94 (05) : 1707 - 1718
  • [7] Structure/function studies of truncated cardiac myosin binding protein C in transgenic mice
    Yang, QL
    Sanbe, A
    Osinska, H
    Klevitsky, R
    Robbins, J
    FASEB JOURNAL, 1999, 13 (04): : A343 - A343
  • [8] Reduced isometric and stretch activated tension of left ventricular papillary muscle from homozygous cardiac myosin binding protein-C transgenic mice.
    Palmer, BM
    McConnell, BK
    Seidman, CE
    Seidman, JG
    Alpert, NR
    Maughan, DW
    CIRCULATION, 2000, 102 (18) : 342 - 342
  • [9] Reduced cross-bridge dependent stiffness of skinned myocardium from mice lacking cardiac myosin binding protein-C
    Palmer, BM
    McConnell, BK
    Li, GH
    Seidman, CE
    Seidman, JG
    Irving, TC
    Alpert, NR
    Maughan, DW
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2004, 263 (01) : 73 - 80
  • [10] Reduced cross-bridge dependent stiffness of skinned myocardium from mice lacking cardiac myosin binding protein-C
    Bradley M. Palmer
    Bradley K. McConnell
    Guo Hua Li
    Christine E. Seidman
    J.G. Seidman
    Thomas C. Irving
    Norman R. Alpert
    David W. Maughan
    Molecular and Cellular Biochemistry, 2004, 263 : 73 - 80