Chimeric antigen receptor T (CAR-T) cells technology has been successfully used in the treatment of B cell-derived hematological tumors and multiple myeloma. CAR-T cells are also being studied in a variety of solid tumors. Current clinical reports on CAR-T cells in the treatment of malignant tumors are abundant. The tumor-killing activity of CAR-T cells and the unique adverse effects of CAR-T cells have been confirmed by many studies. There is evidence that serious adverse events can be life-threatening. CAR-T cells therapy is increasingly used in clinical settings, so it is important to pay attention to its serious adverse events. In this review, we summarized the serious adverse events of CAR-T cells in the treatment of malignant tumors by reading literature and searching relevant clinical studies, and discussed the management and treatment of serious adverse events in an effort to provide theoretical support for clinicians who deal with such patients.
机构:
Lanzhou Univ, Dept Gen Surg, Second Hosp, Lanzhou, Peoples R China
Lanzhou Univ, Key Lab Digest Syst Tumors Gansu Prov, Second Hosp, Lanzhou, Peoples R ChinaLanzhou Univ, Dept Gen Surg, Second Hosp, Lanzhou, Peoples R China
Miao, Lele
Zhang, Zhengchao
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Lanzhou Univ, Dept Gen Surg, Second Hosp, Lanzhou, Peoples R China
Lanzhou Univ, Key Lab Digest Syst Tumors Gansu Prov, Second Hosp, Lanzhou, Peoples R ChinaLanzhou Univ, Dept Gen Surg, Second Hosp, Lanzhou, Peoples R China
Zhang, Zhengchao
Ren, Zhijian
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Lanzhou Univ, Dept Gen Surg, Second Hosp, Lanzhou, Peoples R China
Lanzhou Univ, Key Lab Digest Syst Tumors Gansu Prov, Second Hosp, Lanzhou, Peoples R ChinaLanzhou Univ, Dept Gen Surg, Second Hosp, Lanzhou, Peoples R China
Ren, Zhijian
Tang, Futian
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Lanzhou Univ, Key Lab Digest Syst Tumors Gansu Prov, Second Hosp, Lanzhou, Peoples R ChinaLanzhou Univ, Dept Gen Surg, Second Hosp, Lanzhou, Peoples R China
Tang, Futian
Li, Yumin
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Lanzhou Univ, Dept Gen Surg, Second Hosp, Lanzhou, Peoples R China
Lanzhou Univ, Key Lab Digest Syst Tumors Gansu Prov, Second Hosp, Lanzhou, Peoples R ChinaLanzhou Univ, Dept Gen Surg, Second Hosp, Lanzhou, Peoples R China
机构:
CHU Gabriel Montpied, Serv Oncol Med, Clermont Ferrand, France
Univ Clermont Auvergne, Clermont Ferrand, FranceCHU Gabriel Montpied, Serv Oncol Med, Clermont Ferrand, France
El Ghazzi, Nathan
Italiano, Antoine
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机构:
Inst Bergonie, Unite Phases Precoces, Bordeaux, France
Univ Bordeaux, Bordeaux, FranceCHU Gabriel Montpied, Serv Oncol Med, Clermont Ferrand, France
Italiano, Antoine
Bay, Jacques-Olivier
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CHU Gabriel Montpied, Serv Oncol Med, Clermont Ferrand, France
Univ Clermont Auvergne, Clermont Ferrand, FranceCHU Gabriel Montpied, Serv Oncol Med, Clermont Ferrand, France
Bay, Jacques-Olivier
Douge, Aurore
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机构:
CHU Gabriel Montpied, Serv Oncol Med, Clermont Ferrand, France
Univ Clermont Auvergne, Clermont Ferrand, FranceCHU Gabriel Montpied, Serv Oncol Med, Clermont Ferrand, France