RGS4 genotype is not associated with antipsychotic medication response in schizophrenia

被引：13

作者：

Kampman, O. ^{[1
]}

Illi, A.

Hanninen, K.

Katila, H.

Anttila, S.

Rontu, R.

Mattila, K. M.

Leinonen, E.

Lehtimaki, T.

机构：

[1] Univ Tampere, Sch Med, Tampere 33014, Finland

[2] Tampere Univ Hosp, Ctr Lab Med, Dept Clin Chem, Lab Athersclerosis Genet, Tampere, Finland

[3] Tampere Univ Hosp, Dept Psychiat, Tampere, Finland

[4] Univ Helsinki, Sch Med, Dept Psychiat, FIN-00014 Helsinki, Finland

[5] Univ Helsinki, Cent Hosp, FIN-00014 Helsinki, Finland

来源：

JOURNAL OF NEURAL TRANSMISSION | 2006年 / 113卷 / 10期

关键词：

RGS4; schizophrenia; pharmacogenetics; antipsychotic agents;

D O I：

10.1007/s00702-006-0445-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aims of the present study were to compare the allele frequencies of a common single nucleotide polymorphism located upstream of the regulator of G-protein signaling 4 (RGS4) gene (T > G, Rs 951436) in 219 Finnish patients with schizophrenia and in 389 control subjects, to analyze corresponding frequencies between two different subtypes of 93 schizophrenia patients according to their medication response, and to study the effect of this SNP on age at onset in schizophrenia. The RGS4 (T > G, Rs 951436) genotype was not associated with incidence or age at onset in schizophrenia. Neither was the RGS4 genotype associated with medication response with two different subpopulations with schizophrenia.

引用

页码：1563 / 1568

页数：6

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