Abdominal small round cell tumor with osteoid and EWS/FLi1

被引：12

作者：

Oshima, Y

Kawaguchi, S

Nagoya, S

Wada, T

Kokai, Y

Ikeda, T

Nogami, S

Oya, T

Hirayama, YA

机构：

[1] Sapporo Med Univ, Sch Med, Dept Orthopaed Surg, Lab Biomed Engn,Chuo Ku, Sapporo, Hokkaido 0608543, Japan

[2] Sapporo Med Univ, Sch Med, Div Clin Pathol, Sapporo, Hokkaido 0608543, Japan

[3] Toyama Med & Pharmaceut Univ, Dept Orthopaed Surg, Toyama, Japan

[4] Toyama Med & Pharmaceut Univ, Dept Pathol, Toyama, Japan

[5] Higashi Sapporo Hosp, Div Internal Med, Sapporo, Hokkaido, Japan

来源：

HUMAN PATHOLOGY | 2004年 / 35卷 / 06期

关键词：

small round cell tumor; abdominal; osteoid; EWS/FLI1;

D O I：

10.1016/j.humpath.2004.02.001

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

In this report, we described a case of multiple intraperitoneal tumors. Histologically, the tumors were composed of small round cells with malignant phenotype, necrotic areas, and islands of osteoid matrix in the stroma. In immunohistochemical and molecular analyses, the tumors expressed CD99 and EWS-Fli1 fusion gene. Production of osteoid by small round tumor cells was consistent with the histologic criteria of small-cell osteosarcoma, whereas expression of EWS-Fli1 was a characteristic genetic feature of Ewing's sarcoma family of tumor. Such tumors have been limited to a case in which histologically proven small-cell osteosarcoma of the scapula showed a chromosomal translocation, t(11;22)(q24;q12). (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：773 / 775

页数：3

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