The Impact of Inspiratory Flow Rate on Drug Delivery to the Lungs with Dry Powder Inhalers

被引：79

作者：

Weers, Jeffry ^{[1
]}

Clark, Andy ^{[2
]}

机构：

[1] Novartis Pharmaceut, 150 Ind Rd, San Carlos, CA 94070 USA

[2] Aerogen Pharma, San Mateo, CA USA

来源：

PHARMACEUTICAL RESEARCH | 2017年 / 34卷 / 03期

关键词：

Bronchodilator; Inertial impaction parameter; Inhalation; Total Lung Dose (TLD); METERED-DOSE INHALER; OPTIMAL PARTICLE-SIZE; TERBUTALINE SULFATE; RESPIRATORY-TRACT; CYSTIC-FIBROSIS; INHALATION FLOW; AIR-FLOW; DEPOSITION; TURBUHALER(R); CHILDREN;

D O I：

10.1007/s11095-016-2050-x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Current marketed dry powder inhalers utilize the energy from patient inspiration to fluidize and disperse bulk powder agglomerates into respirable particles. Variations in patient inspiratory flow profiles can lead to marked differences in total lung dose (TLD), and ultimately patient outcomes for an inhaled therapeutic. The present review aims to quantitate the flow rate dependence in TLD observed for a number of drug/device combinations using a new metric termed the Q index. With this data in hand, the review explores key attributes in the design of the formulation and device that impact flow rate dependence. The review also proposes alternative in vitro methods to assess flow rate dependence that more closely align with in vivo observations. Finally, the impact of variations in flow rate on lung function for inhaled bronchodilators is summarized.

引用

页码：507 / 528

页数：22

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