Value of tumor size as a prognostic factor in metastatic colorectal cancer patients after chemotherapy: a population-based study

被引：13
|
作者：
Yan, Qingying [1 ]
Zhang, Kai [1 ,2 ]
Guo, Kaibo [1 ]
Liu, Shan [3 ]
Wasan, Harpreet S. [4 ]
Jin, Huimin [1 ]
Yuan, Li [1 ]
Feng, Guan [1 ]
Shen, Fengfei [1 ]
Shen, Minhe [5 ]
Ma, Shenglin [6 ]
Ruan, Shanming [5 ,6 ]
机构：
[1] Zhejiang Chinese Med Univ, Clin Med Coll 1, Hangzhou 310053, Zhejiang, Peoples R China
[2] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY USA
[3] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Dept Assessment Ctr, Hangzhou 310006, Zhejiang, Peoples R China
[4] Imperial Coll Healthcare NHS Trust, Hammersmith Hosp, Dept Canc Med, London W12 0HS, England
[5] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Dept Med Oncol, Hangzhou, Zhejiang, Peoples R China
[6] Zhejiang Chinese Med Univ, Clin Med Coll 4, Dept Oncol, Hangzhou 310053, Zhejiang, Peoples R China
来源：
FUTURE ONCOLOGY | 2019年 / 15卷 / 15期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
chemotherapy; metastatic colorectal cancer; tumor size; SIDED COLON-CANCER; RISK-FACTORS; ONCOLOGICAL OUTCOMES; THERAPEUTIC APPROACH; CURATIVE RESECTION; SURVIVAL; RECURRENCE; STAGE; IMPACT; PROLIFERATION;
D O I：
10.2217/fon-2018-0785
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: To evaluate the relationship between tumor size and survival in metastatic colorectal cancer (mCRC) patients who received chemotherapy. Materials & methods: SEER database was accessed for eligible patients. Multivariate Cox regression analysis was performed to compare the effect of tumor size on overall survival (OS) and CRC-specific survival (CCSS). Results: Tumor size >= 5cm was an independent risk factor for OS and CCSS in mCRC patients treated with chemotherapy. Tumor size <5cm did not show a survival advantage in patients whose primary tumor site was rectosigmoid junction, while tumor size >= 5cm was associated with poor OS and CCSS in left-and right-sided colorectal cancer. Conclusion: Tumor size >= 5cm was associated with poor prognosis after receiving chemotherapy treatment and a risk factor for survival of mCRC.
引用
收藏
页码：1745 / 1758
页数：14
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