A Carbon Nanocomposite Ionic Liquid Electrode Based on Montmorillonite Nanoclay for Sensitive Voltammetric Determination of Thioridazine

A carbon nanocomposite electrode has been designed by incorporation of montmorillonite nanoclay into the carbon ionic liquid electrode for the electrochemical determination of (10-[2-(1-methyl-2-piperidyl) ethyl]-2-methylthiophenothiazine) (thioridazine). The surface of the proposed electrode was characterized by scanning electron microscopy. Adsorptive stripping voltammetry was applied as a very sensitive analytical method for the determination of sub-micromolar amounts of thioridazine. A linear dynamic range of 0.1-50 mu M with a detection limit of 21 nM thioridazine was obtained. The prepared modified electrode shows several advantages such as simple preparation method, excellent activity in physiological conditions, low detection limit, long-term stability and remarkable voltammetric reproducibility. The modified electrode was employed for the determination of thioridazine in pharmaceutical formulations and blood serum samples.