Expression and prognostic significance of metalloproteases and their inhibitors in luminal A and basal-like phenotypes of breast carcinoma

被引:35
|
作者
Gonzalez, Luis O. [2 ,3 ,4 ]
Corte, Maria D. [2 ,3 ]
Junquera, Sara [3 ]
Gonzalez-Fernandez, Raquel [5 ]
del Casar, Jose M. [1 ,2 ,3 ]
Garcia, Carmen [3 ]
Andicoechea, Alejandro [1 ,2 ,3 ]
Vazquez, Julio [2 ,3 ]
Perez-Fernandez, Roman [5 ]
Vizoso, Francisco J. [1 ,2 ,3 ]
机构
[1] Hosp Jove, Serv Cirugia Gen, Gijon 33290, Spain
[2] Inst Univ Oncol Principado Asturias, Oviedo 33006, Spain
[3] Hosp Jove, Unidad Invest, Gijon 33290, Spain
[4] Hosp Jove, Serv Anat Patol, Gijon 33290, Spain
[5] 15782 Univ Santiago de Compostela, Fac Med, Dept Fisiol, Santiago De Compostela, Spain
关键词
Breast cancer; Matrix metal loproteases; Metastasis; Tissue inhibitors of matrix metalloproteases; MATRIX METALLOPROTEINASES; TISSUE INHIBITORS; CANCER; INVASION; MMP-2; OVEREXPRESSION; CLASSIFICATION; CYTOKERATIN-5; STROMELYSIN; SUBCLASSES;
D O I
10.1016/j.humpath.2008.12.022
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
To analyze the expression and prognostic value of matrix metalloproteases and their tissue inhibitors in luminal A and basal-like breast carcinomas, an immunohistochemical study was performed on cancer specimens from 93 randomly selected patients with invasive primary ductal tumors of the breast (46 with and 47 without distant metastasis) and with luminal A (n = 48) (ER+, HER2-) or basal-like (HER2-, ER-, PgR-) (n = 45) lesions. Luminal B cases were too few to analyze. Specimens were also studied using tissue microarrays and specific antibodies against matrix metalloproteases 1, 2, 7 9, 11, 13, and 14 and tissue inhibitors 1, 2, and 3. There were no significant differences in matrix metalloprotease or tissue inhibitor expression in the 2 phenotypes of tumors. In basal-like carcinomas., high scores for matrix metalloproteases 9 and 11 were significantly associated with a high distant metastasis rate. Likewise, data showed associations between matrix metalloprotease/tissue inhibitor expression by either stromal fibroblasts or mononuclear inflammatory cells and distant relapse-free survival in both tumor phenotypes. In addition, in infiltrating luminal A and basal-like tumors, we identified a prometastatic phenotype of mononuclear inflammatory cells, showing a high matrix metalloprotease/tissue inhibitor molecular profile. Expression of matrix metalloproteases and tissue inhibitors is related to the characteristics of breast tumor cells. As prognostic factors in breast carcinomas of both lurninal A and basal-like phenotypes, our results point to the importance of the expression of matrix metalloproteases and tissue inhibitors by the stromal cells. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码:1224 / 1233
页数:10
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