Serum and glucocorticoid kinase 1 promoted the growth and migration of non-small cell lung cancer cells

被引：29

作者：

Yu Xiaobo ^{[1
]}

Lin Qiang ^{[1
]}

Qin Xiong ^{[1
]}

Ruan Zheng ^{[1
]}

Zhou Jianhua ^{[1
]}

Lin Zhifeng ^{[1
]}

Su Yijiang ^{[1
]}

Jian Zheng ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Thorac Surg, Shanghai 200080, Peoples R China

来源：

GENE | 2016年 / 576卷 / 01期

关键词：

NSCLC; SGK1; Beta-catenin/TCF signaling; Cell growth and migration; PI3K PATHWAY; BETA-CATENIN; PROTEIN-KINASE; SGK; EXPRESSION; SUPPRESSES; PDK1; GENE; PROGRESSION; STATISTICS;

D O I：

10.1016/j.gene.2015.10.072

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Serum and glucocorticoid kinase 1 (SGK1) has been reported to be up -regulated in non-small cell lung cancer (NSCLC). However, its functions in NSCLC remained unclear. Here, SGK1 was found to be up -regulated in NSCLC samples. Over -expression of SGK1 promoted the growth and migration of NSCLC cells, while down -regulation of SGK1 inhibited the growth, migration and metastasis of NSCLC cells. SGK1 promoted the phosphorylation of GSK3 beta and the accumulation of beta-catenin, up -regulation of the target genes downstream of beta-catenin/TCF signaling, and activating the transcriptional activity of beta-catenin/TCF complex. Collectively, SGK1 might promote the progression of NSCLC through activating beta-catenin/TCF signaling. (C) 2015 Published by Elsevier B.V.

引用

页码：339 / 346

页数：8

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