Synthesis and Characterization of Novel Biocompatible Four-arm Star-shaped Copolymers by Using a New Tetramethacrylate Core

被引：7

作者：

Heidarpour, Ramin ^{[1
]}

Alimohammadi, Somayeh ^{[2
]}

Salehi, Roya ^{[2
]}

Hemmati, Salar ^{[2
]}

Taghvaei-Ganjali, Saeed ^{[1
]}

机构：

[1] Islamic Azad Univ, Dept Chem, North Tehran Branch, Tehran 1913674711, Iran

[2] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz 5165665811, Iran

来源：

FIBERS AND POLYMERS | 2014年 / 15卷 / 03期

关键词：

Star-shaped block copolymer; Biocompatible copolymer; 4-arm star-shaped copolymer; Multiacrylic dendrimer; Tetramethacrylate monomer; BLOCK-COPOLYMERS; POLYMERS; MICELLES;

D O I：

10.1007/s12221-014-0465-8

中图分类号：

TB3 [工程材料学]; TS1 [纺织工业、染整工业];

学科分类号：

0805 ; 080502 ; 0821 ;

摘要：

The objective of this study was to synthesize and characterize two novel four-arm star-shaped copolymers of N-isopropylacrylamide (NIPAAm), methacrylic acid (MAA), N,N-(dimethylamino) ethyl methacrylate (DMAEMA) and 1-vinyl-2-pyrrolidone (VP) that was initiated from a new tetramethacrylate monomer (TMAM) as the core by the free radical polymerization approach. Novel multiacrylic monomer was synthesized via three key consecutive reactions. All the intermediates and the final product have been fully characterized. The polymerization reaction was conducted by the core first method and the star-shaped copolymers were analyzed by FT-W, H-1 NMR and Thermo-Gravimetric Analysis (TGA). MTT assay was used to evaluate in vitro cytotoxicity of the star copolymers on lung cancer cell lines. These star copolymers showed no in vitro cytotoxicity to A549 cells. The results showed that these copolymers can be promising drug carriers because they showed no in vitro cytotoxicity and they have various functional groups for association and interaction with drugs.

引用

页码：465 / 471

页数：7

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[1] Synthesis and characterization of novel biocompatible four-arm star-shaped copolymers by using a new tetramethacrylate core
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Somayeh Alimohammadi
Roya Salehi
Salar Hemmati
Saeed Taghvaei-Ganjali
[J]. Fibers and Polymers, 2014, 15 : 465 - 471
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