A novel receptor-based surface-plasmon-resonance affinity biosensor for highly sensitive and selective detection of dopamine

被引：22
|
作者：
Kumbhat, Sunita
Shankaran, Dhesingh Ravi
Kim, Sock Jin
Gobi, K. Vengatajalabathy
Joshi, Vinod
Miura, Norio [1 ]
机构：
[1] Kyushu Univ, Art Sci & Technol Ctr Cooperat Res, Kasuga, Fukuoka 8168580, Japan
[2] JNV Univ, Dept Chem, Jodhpur 342003, Rajasthan, India
[3] Desert Med Res Ctr, Div Virol & Mol Biol, Jodhpur 342003, Rajasthan, India
[4] Japan Soc Promot Sci, Tokyo 1028471, Japan
来源：
CHEMISTRY LETTERS | 2006年 / 35卷 / 06期
关键词：
D O I：
10.1246/cl.2006.678
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We have established a new surface-plasmon-resonance (SPR) based affinity biosensor for highly sensitive and selective detection of dopamine (DA) employing a D-3 dopamine receptor (D-RC) and a home-made DA-bovine serum albumin (DA-BSA) conjugate. The proposed biosensor is simple, reproducible and exhibit excellent sensitivity for DA (detection limit = 85 pg/mL (ppt)) without any significant interference from ascorbic acid (AA), uric acid (UA), and other DA analogues.
引用
收藏
页码：678 / 679
页数：2
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