Systemic Regulators of Skeletal Muscle Regeneration in Obesity

被引：32
|
作者：
Sinha, Indranil [1 ]
Sakthivel, Dharaniya [1 ]
Varon, David E. [1 ]
机构：
[1] Brigham & Womens Hosp, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA
来源：
FRONTIERS IN ENDOCRINOLOGY | 2017年 / 8卷
关键词：
skeletal muscle; obesity; inflammation; metabolism; insulin; HIGH-FAT DIET; KOREAN SARCOPENIC OBESITY; INSULIN-RESISTANCE; ADIPOSE-TISSUE; LIVER-DISEASE; STEM-CELLS; FIBRO/ADIPOGENIC PROGENITORS; MITOCHONDRIAL DYSFUNCTION; GLUCOSE-HOMEOSTASIS; DIABETES-MELLITUS;
D O I：
10.3389/fendo.2017.00029
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Skeletal muscle maintenance is a dynamic process and undergoes constant repair and regeneration. However, skeletal muscle regenerative capacity declines in obesity. In this review, we focus on obesity-associated changes in inflammation, metabolism, and impaired insulin signaling, which are pathologically dysregulated and ultimately result in a loss of muscle mass and function. In addition, we examine the relationships between skeletal muscle, liver, and visceral adipose tissue in an obese state.
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页数：7
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