Process Improvement on the Synthesis of Telavancin-Derivative of Vancomycin

被引：0

作者：

Liu, Luo ^{[1
]}

Pan, Min ^{[1
]}

Zhou, Jinshan ^{[1
]}

Yang, Jinwei ^{[1
]}

机构：

[1] Zhejiang Med Co Ltd, Xinchang Pharma, Shaoxing 312500, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 35卷 / 11期

关键词：

telavancin; vancomycin; process improvement;

D O I：

10.6023/cjoc201505029

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This article was the process improvement of telavancin synthesis. The key intermediate N-Fmoc-decyl-amino-acetaldehyde was obtained through continuous reaction method, followed by one-pot condensation and Mannich reaction. Telavancin hydrochloride was finnally obtained via reversed phase silica gel. The HPLC purity and total yield of this route were higher than the existing literatures. It was easy to operate, environmentally friendly, lower costs, and suitable for industrialized production.

引用

页码：2437 / 2440

页数：4

共 8 条

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