Synaptic plasticity and phosphorylation

被引：157
|
作者：
Lee, Hey-Kyoung [1 ]
机构：
[1] Univ Maryland, NACS Program, College Pk, MD 20742 USA
来源：
PHARMACOLOGY & THERAPEUTICS | 2006年 / 112卷 / 03期
关键词：
phosphoproteins; postsynaptic; long-term potentiation; long-term depression; homeostatic plasticity;
D O I：
10.1016/j.pharmthera.2006.06.003
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A number of neuronal functions, including synaptic plasticity, depend on proper regulation of synaptic proteins, many of which can be rapidly regulated by phosphorylation. Neuronal activity controls the function of these synaptic proteins by exquisitely regulating the balance of various protein kinase and protein phosphatase activity. Recent understanding of synaptic plasticity mechanisms underscores important roles that these synaptic phosphoproteins play in regulating both pre- and post-synaptic functions. This review will focus on key postsynaptic phosphoproteins that have been implicated to play a role in synaptic plasticity. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码：810 / 832
页数：23
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