Concise Synthesis of Functionalized Cyclobutene Analogues for Bioorthogonal Tetrazine Ligation

被引：0

作者：

Sun, Jiayu ^{[1
]}

Li, Jie ^{[1
]}

Sun, Hongbao ^{[1
]}

Li, Chunling ^{[2
,3
]}

Wu, Haoxing ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Radiol, Guo Xue Xiang 37, Chengdu 610041, Peoples R China

[2] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Neurosurg, Chengdu 610072, Peoples R China

[3] Chinese Acad Sci, Sichuan Translat Med Res Hosp, Chengdu 610072, Peoples R China

来源：

MOLECULES | 2021年 / 26卷 / 02期

关键词：

functionalized cyclobutene analogues; concise synthesis; tetrazine ligation; bioorthogonal chemistry; TRANS-CYCLOOCTENE; DRUG-RELEASE; CYCLOPROPENES; REACTIVITY; CHEMISTRY; PROBE; TAGS;

D O I：

10.3390/molecules26020276

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel bioorthogonal tools enable the development of new biomedical applications. Here we report the concise synthesis of a series of aryl-functionalized cyclobutene analogues using commercially available starting materials. Our study demonstrates that cyclobutene acts as a small, strained dienophile to generate stable substrates suitable for bioorthogonal tetrazine ligation.

引用

页数：13

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