An efficient synthesis of pyrrolo[2,3-d]pyrimidines via inverse electron demand Diels-Alder reactions of 2-amino-4-cyanopyrroles with 1,3,5-triazines

被引：60
|
作者：
Dang, Q [1 ]
Gomez-Galeno, JE [1 ]
机构：
[1] Metabasis Therapeut Inc, Dept Med Chem, San Diego, CA 92121 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 24期
关键词：
D O I：
10.1021/jo026309d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The scope of the inverse electron demand Diels-Alder reaction of 2-amino-4-cyanopyrroles (3a-e) with 1,3,5-triazines (1, 2) is reported. This methodology is suitable for one-pot syntheses of highly substituted and highly functionalized pyrrolo[2,3-d]pyrimidines that are the central heterocyclic nucleus of various nucleoside natural products such as toyocamycin, sangivamycin, and tubercidin.
引用
收藏
页码：8703 / 8705
页数：3
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