Macrophages decide between regeneration and fibrosis in muscle

被引：46
|
作者：
Munoz-Canoves, Pura [1 ,2 ]
Serrano, Antonio L. [1 ]
机构：
[1] Pompeu Fabra Univ UPF, Dept Expt & Hlth Sci, Cell Biol Grp, CIBER Neurodegenerat Dis CIBERNED, Barcelona, Spain
[2] Inst Catalana Recerca & Estudis Avancats, Barcelona, Spain
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2015年 / 26卷 / 09期
关键词：
regeneration; fibrosis; macrophages; fibro/adipogenic progenitors; nilotinib; SKELETAL-MUSCLE; FIBRO/ADIPOGENIC PROGENITORS; INJURY; MYOGENESIS; REPAIR;
D O I：
10.1016/j.tem.2015.07.005
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Defective muscle regeneration is usually accompanied by excessive matrix accumulation (fibrosis). A recent study reveals how this fibrotic process is prevented to allow successful regeneration, through a timely interplay between macrophages and fibro/adipogenic progenitor cells. This has biomedical relevance for fibrotic muscular dystrophies.
引用
收藏
页码：449 / 450
页数：2
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