Volitional Regulation of the Supplementary Motor Area with fMRI-BCI neurofeedback in Parkinson's Disease: A Pilot Study

被引：0

作者：

Buyukturkoglu, Korhan ^{[1
,2
]}

Rana, Mohit ^{[1
,2
]}

Ruiz, Sergio ^{[3
]}

Hackley, Steven A. ^{[4
]}

Soekadar, Surjo R. ^{[2
,5
]}

Birbaumer, Niels ^{[2
,6
]}

Sitaram, Ranganatha ^{[2
,7
,8
]}

机构：

[1] Univ Tubingen, Int Max Planck Res Sch, Grad Sch Neural & Behav Sci, Tubingen, Germany

[2] Eberhard Karls Univ Tubingen, Inst Med Psychol & Behav Neurobiol, D-72074 Tubingen, Germany

[3] Pontificia Univ Catolica Chile, Dept Psiquiatria, Ctr Interdisciplinario Neurociencia, Escuela Med, Santiago, Chile

[4] Univ Missouri, Dept Psychol Sci, Columbia, MO 65211 USA

[5] Univ Hosp Tubingen, Dept Psychiat & Psychotherapy, Appl Neurotechnol Lab, Tubingen, Germany

[6] Osped San Camillo, IRCCS, Venice, Italy

[7] Univ Florida, Dept Biomed Engn, Gainesville, FL 32611 USA

[8] Sri Chitra Tirunal Inst Med Sci & Technol, Thiruvananthapuram 695011, Kerala, India

来源：

2013 6TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER) | 2013年

关键词：

MOVEMENTS; ACTIVATION; DISORDERS; LEVODOPA; PET;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

It is hypothesized that a dysfunction of the supplementary motor area (SMA), secondary to a deficit of the nigrostriatal dopamine system, partially contributes to the symptomatology of Parkinson's disease (PD), i.e., akinesia. In this pilot study we investigated the effect of real-time fMRI neurofeedback based volitional up-regulation of the SMA on hand motor performance of one PD patient and 3 healthy volunteers. The effect of learned self-regulation was evaluated with speeded, bimanual, sequenced button-pressing trials, assessed immediately after each baseline and up-regulation block. Our pilot results indicate that volitional up-regulation of SMA is accompanied by slowing of sequenced button presses.

引用

页码：677 / 681

页数：5

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