Dopamine influences attentional rate modulation in Macaque posterior parietal cortex

被引:4
|
作者
van Kempen, Jochem [1 ]
Brandt, Christian [2 ,3 ]
Distler, Claudia [4 ]
Bellgrove, Mark A. [5 ]
Thiele, Alexander [1 ]
机构
[1] Newcastle Univ, Biosci Inst, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
[2] Odense Univ Hosp, Res Unit ORL Head & Neck Surg & Audiol, Odense, Denmark
[3] Univ Southern Denmark, Odense, Denmark
[4] Ruhr Univ Bochum, Allgemeine Zool & Neurobiol, D-44801 Bochum, Germany
[5] Monash Univ, Sch Psychol Sci, Turner Inst Brain & Mental Hlth, Melbourne, Vic 3800, Australia
基金
英国医学研究理事会; 英国惠康基金;
关键词
PRIMATE PREFRONTAL CORTEX; SACCADE TARGET SELECTION; SUPERIOR COLLICULUS; SPATIAL ATTENTION; WORKING-MEMORY; ACETYLCHOLINE-RELEASE; COGNITIVE MODULATION; NEURONAL-ACTIVITY; CEREBRAL-CORTEX; RECEPTORS;
D O I
10.1038/s41598-022-10634-w
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Cognitive neuroscience has made great strides in understanding the neural substrates of attention, but our understanding of its neuropharmacology remains incomplete. Although dopamine has historically been studied in relation to frontal functioning, emerging evidence suggests important dopaminergic influences in parietal cortex. We recorded single- and multi-unit activity whilst iontophoretically administering dopaminergic agonists and antagonists while rhesus macaques performed a spatial attention task. Out of 88 units, 50 revealed activity modulation by drug administration. Dopamine inhibited firing rates according to an inverted-U shaped dose-response curve and increased gain variability. D1 receptor antagonists diminished firing rates according to a monotonic function and interacted with attention modulating gain variability. Finally, both drugs decreased the pupil light reflex. These data show that dopamine shapes neuronal responses and modulates aspects of attentional processing in parietal cortex.
引用
收藏
页数:14
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