A nano-sized gel-in-oil suspension for transcutaneous protein delivery

被引：8
|
作者：
Hardiningtyas, Safrina Dyah [1 ]
Nagao, Seiya [2 ]
Yamamoto, Emiko [2 ]
Shirakigawa, Nana [2 ]
Wakabayashi, Rie [1 ]
Goto, Masahiro [1 ,3 ]
Ijima, Hiroyuki [2 ]
Kamiya, Noriho [1 ,3 ]
机构：
[1] Kyushu Univ, Grad Sch Engn, Dept Appl Chem, Nishi Ku, Motooka 744, Fukuoka, Fukuoka 8190395, Japan
[2] Kyushu Univ, Grad Sch Engn, Dept Chem Engn, Nishi Ku, Motooka 744, Fukuoka, Fukuoka 8190395, Japan
[3] Kyushu Univ, Ctr Future Chem, Div Biotechnol, Fukuoka, Fukuoka, Japan
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2019年 / 567卷
关键词：
Gelatin; Phycocyanin; Protein; Transdermal delivery; C-PHYCOCYANIN; DRUG-DELIVERY; SKIN; VITRO; NANODISPERSION; MICROEMULSIONS; MICELLES; BEHAVIOR;
D O I：
10.1016/j.ijpharm.2019.118495
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We developed a new oil-based delivery system for transdermal protein delivery, a gel-in-oil (G/O) nanosuspension, where gelatin-based hydrogel was coated with hydrophobic surfactants. The high entrapment efficiency of a model protein, phycocyanin (PC), into nano-sized gelatin hydrogel particles was achieved. Spectroscopic evaluation of PC suggested that the G/O nanosuspension could retain the functional form of PC in isopropyl myristate. In vitro skin permeation studies showed that the G/O nanosuspension facilitated the delivery of PC through the stratum corneum of Yucatan micropig skin.
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页数：6
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