Manipulation of metabolism in complex eukaryotic systems to control cellular state

被引:3
|
作者
Su, Amy M. [1 ]
Styczynski, Mark P. [1 ]
机构
[1] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA
基金
美国国家科学基金会;
关键词
PLURIPOTENT STEM-CELLS; SYNTHETIC PHOSPHOETHANOLAMINE; SCALE EXPANSION; SOMATIC-CELLS; IN-VITRO; DIFFERENTIATION; CANCER; PROLINE; MOUSE; GLYCOLYSIS;
D O I
10.1016/j.coche.2015.08.004
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The regulation of metabolism is critical to many important cellular processes in higher eukaryotes, and metabolites themselves can have significant regulatory potential in complex phenotypes. Thus, external control of metabolism for both biotechnological and biomedical ends is of great importance. There has been increasing emphasis on using non-genetic approaches for direct, transient control of metabolism and cellular state, with particularly promising applications in stem cell biomanufacturing and cancer. Metabolite-based methods have been used to facilitate expansion of stem cells, to control and prevent their differentiation, and to reprogram cells to a pluripotent state. Similar approaches are also being explored to inhibit the growth of cancer cells.
引用
收藏
页码:63 / 69
页数:7
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