Oxygen management in mechanically ventilated patients: A multicenter prospective observational study

被引：7

作者：

Egi, Moritoki ^{[1
]}

Kataoka, Jun ^{[2
]}

Ito, Takashi ^{[3
]}

Nishida, Osamu ^{[4
]}

Yasuda, Hideto ^{[5
]}

Okamaoto, Hiroshi ^{[6
]}

Shimoyama, Akira ^{[7
]}

Izawa, Masayo ^{[8
]}

Matsumoto, Shinsaku ^{[9
]}

Furushima, Nana ^{[1
]}

Yamashita, Shigeki ^{[10
]}

Takada, Koji ^{[11
]}

Ohtsuka, Masahide ^{[12
]}

Fujisaki, Noritomo ^{[13
]}

Shime, Nobuaki ^{[14
]}

Inagaki, Nobuhiro ^{[15
]}

Taira, Yasuhiko ^{[16
]}

Yatabe, Tomoaki ^{[17
]}

Nitta, Kenichi ^{[18
]}

Yokoyama, Takeshi ^{[19
]}

Kushimoto, Shigeki ^{[20
]}

Tokunaga, Kentaro ^{[21
]}

Doi, Matsuyuki ^{[22
]}

Masuda, Takahiro ^{[23
]}

Miki, Yasuo ^{[24
]}

Matsuda, Kenichi ^{[25
]}

Asaga, Takehiko ^{[26
]}

Hazama, Keita ^{[27
]}

Matsuyama, Hiroki ^{[28
]}

Nishimura, Masaji ^{[8
]}

Mizobuchi, Satoshi ^{[1
]}

机构：

[1] Kohe Univ Hosp, Dept Anesthesiol, Kobe, Hyogo, Japan

[2] Tokyo Bay Urayasu Ichikawa Med Ctr, Dept Crit Care Med, Chiba, Japan

[3] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Emergency & Intens Care Med, Kagoshima, Japan

[4] Fujita Hlth Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Toyoake, Aichi, Japan

[5] Kameda Med Ctr, Dept Intens Care Med, Chiba, Japan

[6] Kurashiki Cent Hosp, Dept Emergency Med, Kurashiki, Okayama, Japan

[7] Jichi Med Univ, Saitama Med Ctr, Dept Emergency Med, Saitama, Japan

[8] Tokushima Univ Hosp, Emergency & Crit Care Med, Tokushima, Japan

[9] Hiroshima City Hiroshima Citizens Hosp, Dept Anesthesia & Intens Care, Hiroshima, Japan

[10] Kurashiki Cent Hosp, Dept Anesthesiol, Okayama, Japan

[11] Toyonaka City Hosp, Dept Anestitesiol, Osaka, Japan

[12] Yokohama City Univ, Dept Intens Care Med, Med Ctr, Yokohama, Kanagawa, Japan

[13] Hyogo Coll Med, Dept Emergency Disaster & Crit Care Med, Nishinomiya, Hyogo, Japan

[14] Hiroshima Univ, Inst Biomed & Hlth Sci, Dept Emergency & Crit Care Med, Hiroshima, Japan

[15] Oita City Med Assoc, Almeida Mem Hosp, Dept Emergency & Crit Care Med, Oita, Japan

[16] St Marianna Univ, Sch Med, Dept Emergency & Crit Care Med, Kawasaki, Kanagawa, Japan

[17] Kochi Med Sch, Dept Anesthesiol & Intens Care Med, Kochi, Japan

[18] Shinshu Univ, Sch Med, Dept Emergency & Crit Care Med, Nagano, Japan

[19] Teine Keijinkai Hosp, Dept Anesthesiol, Intens Care Unit, Sapporo, Hokkaido, Japan

[20] Tohoku Univ, Grad Sch Med, Div Emergency & Crit Care Med, Sendai, Miyagi, Japan

[21] Kumamoto Univ Hosp, Dept Intens Care Med, Kumamoto, Japan

[22] Hamamatsu Univ Hosp, Intens Care Unit, Shizuoka, Japan

[23] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Crit Care Med, Tokyo, Japan

[24] Aichi Med Univ Hosp, Adv Crit Care Ctr, Nagakute, Aichi, Japan

[25] Univ Yamanashi, Sch Med, Dept Emergency & Crit Care Med, Chuo, Yamanashi, Japan

[26] Kagawa Univ Hosp, Intens Care Unit, Miki, Kagawa, Japan

[27] Kawasaki Med Sch, Dept Anesthesiol & Intens Care Med, Okayama, Japan

[28] Japanese Red Cross Kyoto Daiichi Hosp, Dept Anesthesia, Kyoto, Japan

来源：

JOURNAL OF CRITICAL CARE | 2018年 / 46卷

关键词：

Hyperoxemia; Arterial oxygen; Fraction of inspired oxygen; Mechanical ventilation; Prospective; Multicenter; INTENSIVE-CARE-UNIT; NORMOBARIC HYPEROXIA; MORTALITY; THERAPY;

D O I：

10.1016/j.jcrc.2018.03.024

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Purpose: To observe arterial oxygen in relation to fraction of inspired oxygen (FIO2) during mechanical ventilation (MV). Materials and methods: In this multicenter prospective observational study, we included adult patients required MV for > 48 h during the period from March to May 2015. We obtained FIO2, PaO2 and SaO(2) from commencement of MV until the 7th day of MV in the ICU. Results: We included 454 patients from 28 ICUs in this study. The median APACHE II score was 22. Median values of FIO2,PaO2 and SaO(2) were 0.40, 96 mm Hg and 98%. After day two, patients spent most of their time with a FIO2 between 0.3 and 0.49 with median PaO2 of approximately 90 mm Hg and SaO(2) of 97%. PaO2 was >= 100 mm Hg during 47.2% of the study period and was >= 130 mm Hg during 18.4% of the study period. FIO2 was more likely decreased when PaO2 was >= 130 mm Hg or SaO(2) was >= 99% with a FIO2 of 0.5 or greater. When FIO2 was < 0.5, however, FIO2 was less likely decreased regardless of the value of PaO2 and SaO(2). Conclusions: In our multicenter prospective study, we found that hyperoxemia was common and that hyperoxemia was not corrected. (c) 2018 Elsevier Inc. All rights reserved.

引用

页码：1 / 5

页数：5

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