Anodic stripping voltammetric determination of aurothiomalate in urine using a screen-printed carbon electrode

被引:10
|
作者
Bergamini, Marcio F. [1 ]
Boldrin Zanoni, Maria Valnice [1 ]
机构
[1] UNESP, Inst Quim, Dept Quim Analit, BR-14801970 Araraquara, SP, Brazil
关键词
sodium aurothiomalate; gold(I) thiolate determination; screen-printed electrode; gold-base drugs;
D O I
10.1002/elan.200603534
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
This work describes an electroanalytical method for determining gold(I) thiomalate, aurothiomalate, widely used for treatment of reumatoid arthiritis, using a screen-printed carbon electrode (SPCE). Aurothiomalate (AuTM) was determined indirectly at the same electrode by accumulating it first at -1.5 V vs. printed carbon. At this potential in the adsorbed state, the AuTM is reduced to Au(0), which is then oxidized at two steps at -0.22 V and +0.54 V on SPCE. Using optimized conditions of 60 s deposition time, -1.5 V (vs. printed carbon) accumulation potential, 100 mV s(-1) scan rate, linear calibration graphs can be obtained by monitoring the peak at +0.54 V for AuTM in HCl 0.1 mol L-1 from 1.43 x 10(-6) to 1.55 x 10(-4) mol L-1. A limit of detection obtained was 6.50 x 10(-7) mol L-1, and the relative standard deviation from five measurements of 3.0 x 10(-5) mol L-1 AuTM is 4.5%. The method was successfully applied for AuTM determination in human urine sample.
引用
收藏
页码:1457 / 1462
页数:6
相关论文
共 50 条
  • [1] Anodic Voltammetric determination of gemifloxacin using screen-printed carbon electrode
    Radi, Abd-Elgawad
    Khafagy, Amira
    El-shobaky, Amira
    El-mezayen, Hatem
    [J]. JOURNAL OF PHARMACEUTICAL ANALYSIS, 2013, 3 (02) : 132 - 136
  • [2] Anodic voltammetric determination of gemifloxacin using screen-printed carbon electrode
    Abd-Elgawad Radi
    Amira Khafagy
    Amira El-shobaky
    Hatem El-mezayen
    [J]. Journal of Pharmaceutical Analysis, 2013, 3 (02) : 132 - 136
  • [3] Adsorptive Stripping Voltammetric Determination of Amaranth and Tartrazine in Drinks and Gelatins Using a Screen-Printed Carbon Electrode
    Perdomo, Yeny
    Arancibia, Veronica
    Garcia-Beltran, Olimpo
    Nagles, Edgar
    [J]. SENSORS, 2017, 17 (11)
  • [4] Improved anodic stripping voltammetric detection of zinc on a disposable screen-printed gold electrode
    da Silva, Sarah M.
    Squissato, Andre L.
    Rocha, Diego P.
    Vasconcellos, Maria L. S.
    Ferreira, Rafael de Q.
    Richter, Eduardo M.
    Munoz, Rodrigo A. A.
    [J]. IONICS, 2020, 26 (05) : 2611 - 2621
  • [5] Improved anodic stripping voltammetric detection of zinc on a disposable screen-printed gold electrode
    Sarah M. da Silva
    André L. Squissato
    Diego P. Rocha
    Maria L. S. Vasconcellos
    Rafael de Q. Ferreira
    Eduardo M. Richter
    Rodrigo A. A. Munoz
    [J]. Ionics, 2020, 26 : 2611 - 2621
  • [6] Development of an anodic stripping voltammetric assay, using a disposable mercury-free screen-printed carbon electrode, for the determination of zinc in human sweat
    Crew, A.
    Cowell, D. C.
    Hart, J. P.
    [J]. TALANTA, 2008, 75 (05) : 1221 - 1226
  • [7] Voltammetric determination of doxycycline in feedstock using modified carbon screen-printed electrode
    M. S. Tiwari
    R. G. Thorat
    B. B. Popatkar
    V. V. Borge
    A. K. Kadu
    [J]. Analytical Sciences, 2023, 39 : 1889 - 1899
  • [8] Voltammetric determination of doxycycline in feedstock using modified carbon screen-printed electrode
    Tiwari, M. S.
    Thorat, R. G.
    Popatkar, B. B.
    Borge, V. V.
    Kadu, A. K.
    [J]. ANALYTICAL SCIENCES, 2023, 39 (11) : 1889 - 1899
  • [9] Stripping Voltammetric Determination of Mercury in Fish Oil Capsules Using a Screen-printed Gold Electrode
    Squissato, Andre L.
    Rocha, Diego P.
    Almeida, Eduardo S.
    Richter, Eduardo M.
    Munoz, Rodrigo A. A.
    [J]. ELECTROANALYSIS, 2018, 30 (01) : 20 - 23
  • [10] Anodic stripping voltammetry with a heated mercury film on a screen-printed carbon electrode
    Jasinski, M
    Gründler, P
    Flechsig, GU
    Wang, J
    [J]. ELECTROANALYSIS, 2001, 13 (01) : 34 - 36