Reduced rate of knee extensor torque development in older adults with knee osteoarthritis is associated with intrinsicmuscle contractile deficits

被引:25
|
作者
Callahan, Damien M. [1 ]
Tourville, Timothy W. [2 ]
Slauterbeck, James R. [2 ]
Ades, Philip A. [1 ]
Stevens-Lapsley, Jennifer [4 ]
Beynnon, Bruce D. [2 ]
Toth, Michael J. [1 ,2 ,3 ]
机构
[1] Univ Vermont, Coll Med, Dept Med, Burlington, VT 05405 USA
[2] Univ Vermont, Coll Med, Dept Orthopaed & Rehabil, Burlington, VT 05405 USA
[3] Univ Vermont, Coll Med, Dept Mol Physiol & Biophys, Burlington, VT 05405 USA
[4] Univ Colorado, Dept Phys Med & Rehabil, Denver, CO 80202 USA
关键词
Single muscle fiber; Velocity; Skinned fiber; SKELETAL-MUSCLE FIBERS; SINGLE MOTOR UNITS; FORCE DEVELOPMENT; SHORTENING VELOCITY; NEUROMUSCULAR ACTIVATION; BALLISTIC CONTRACTIONS; TRAINING ALTERS; HEART-FAILURE; ARTHROPLASTY; POWER;
D O I
10.1016/j.exger.2015.08.016
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
We examined the effect of knee osteoarthritis on the rate of torque development (RTD) of the knee extensors in older adults with advanced-stage knee osteoarthritis (OA; n=15) and recreationally-active controls (n= 15) of similar age, sex and health status, as well as the relationship between RTD and the size and contractility of single muscle fibers. OA participants had lower RTD when expressed in absolute terms (Nm/ms). There were sex differences in peak RTD (P < 0.05), with greater RTD in men, but no group by sex interaction effects for any variables. The lower RTD in OA versus controls was not explained by variation between groups in the fiber type admixture of the muscle, and was mitigated when RTD was normalized to peak torque (PT). In knee OA volunteers, we found strong correlations between the RTD expressed relative to PT and the velocity of contraction of single myosin heavy chain (MHC) I and IIA/Xmuscle fibers (r=0.652 and 0.862; both P < 0.05) and power output of MHC I fibers (r=0.642; P < 0.05). In controls, RTD relative to PT was related to fiber cross-sectional area of MHC IIA/X fibers (r = 0.707; P < 0.05), but not measures of single fiber contractile performance. To our knowledge, these results represent the first demonstration that variation in whole muscle contractile kinetics in patients with advanced-stage knee osteoarthritis and healthy older adults is related, in part, to the size and function of single muscle fibers. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码:16 / 21
页数:6
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