Fluorescence diffuse optical tomography using upconverting nanoparticles

被引：48
|
作者：
Xu, Can T. [1 ]
Axelsson, Johan [1 ]
Andersson-Engels, Stefan [1 ]
机构：
[1] Lund Univ, Dept Phys, S-22100 Lund, Sweden
来源：
APPLIED PHYSICS LETTERS | 2009年 / 94卷 / 25期
基金：
瑞典研究理事会;
关键词：
biological tissues; fluorescence; nanobiotechnology; nanoparticles; optical tomography; phantoms; photoluminescence; sodium compounds; thulium; ytterbium; yttrium compounds; SMALL ANIMALS; QUANTUM DOTS;
D O I：
10.1063/1.3156857
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
Fluorescence diffuse optical tomography (FDOT) can provide important information in biomedical studies. In this ill-posed problem, suppression of background tissue autofluorescence is of utmost importance. We report a method for autofluorescence-insensitive FDOT using nonlinear upconverting nanoparticles (NaYF4:Yb3+/Tm3+) in a tissue phantom under excitation intensities well below tissue-damage thresholds. Even with the intrinsic autofluorescence from the phantom only, the reconstruction of the nanoparticles is of much better quality than the reconstruction of a Stokes-shifting dye. In addition, the nonlinear power dependence leads to more confined reconstructions and may increase the resolution in FDOT.
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页数：3
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