NVX-CoV2373 vaccine protects cynomolgus macaque upper and lower airways against SARS-CoV-2 challenge

被引：174

作者：

Guebre-Xabier, Mimi ^{[1
]}

Patel, Nita ^{[1
]}

Tian, Jing-Hui ^{[1
]}

Zhou, Bin ^{[1
]}

Maciejewski, Sonia ^{[1
]}

Lam, Kristal ^{[1
]}

Portnoff, Alyse D. ^{[1
]}

Massare, Michael J. ^{[1
]}

Frieman, Matthew B. ^{[2
]}

Piedra, Pedro A. ^{[3
,4
]}

Ellingsworth, Larry ^{[1
]}

Glenn, Gregory ^{[1
]}

Smith, Gale ^{[1
]}

机构：

[1] Novavax Inc, 21 Firstfield Rd, Gaithersburg, MD 20878 USA

[2] Univ Maryland, Sch Med, 685 West Baltimore St, Baltimore, MD 21201 USA

[3] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA

[4] Baylor Coll Med, Pediat, Houston, TX 77030 USA

来源：

VACCINE | 2020年 / 38卷 / 50期

关键词：

SARS-CoV-2; COVID-19; Spike glycoprotein; NVX-CoV2373; nanoparticles; Matrix-M adjuvant; Nonhuman primate;

D O I：

10.1016/j.vaccine.2020.10.064

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There is an urgent need for a safe and protective vaccine to control the global spread of SARS-CoV-2 and prevent COVID-19. Here, we report the immunogenicity and protective efficacy of a SARS-CoV-2 subunit vaccine (NVX-CoV2373) produced from the full-length SARS-CoV-2 spike (S) glycoprotein stabilized in the prefusion conformation. Cynomolgus macaques (Macaca fascicularis) immunized with NVX-CoV2373 and the saponin-based Matrix-MTM adjuvant induced anti-S antibody that was neutralizing and blocked binding to the human angiotensin-converting enzyme 2 (hACE2) receptor. Following intranasal and intratracheal challenge with SARS-CoV-2, immunized macaques were protected against upper and lower infection and pulmonary disease. (C) 2020 The Authors. Published by Elsevier Ltd.

引用

页码：7892 / 7896

页数：5

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