State-Dependent Crosslinking in IKS Demonstrates a Closed-State Interaction between KCNE1 at F57 and KCNQ1 that Inhibits Channel Opening

被引：0
|
作者：
Murray, Christopher I. [1 ]
Maurice, Yasmeen [1 ]
Eldstrom, Jodene [1 ]
Fedida, David [1 ]
机构：
[1] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada
来源：
BIOPHYSICAL JOURNAL | 2014年 / 106卷 / 02期
关键词：
D O I：
10.1016/j.bpj.2013.11.141
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
引用
收藏
页码：16A / 16A
页数：1
相关论文
共 10 条
  • [1] Photo-Cross-Linking of IKs Demonstrates State-Dependent Interactions between KCNE1 and KCNQ1
    Westhoff, Maartje
    Murray, Christopher I.
    Eldstrom, Jodene
    Fedida, David
    BIOPHYSICAL JOURNAL, 2017, 113 (02) : 415 - 425
  • [2] KCNQ1 and KCNE1 in the IKs channel complex make state-dependent contacts in their extracellular domains
    Xu, Xulin
    Jiang, Min
    Hsu, Kai-Ling
    Zhang, Mei
    Tseng, Gea-Ny
    JOURNAL OF GENERAL PHYSIOLOGY, 2008, 131 (06): : 589 - 603
  • [3] State Dependent Photo-Crosslinking of the IKS Channel Complex Demonstrates Movement of KCNE1 at Pre-Opening Membrane Potentials
    Murray, Christopher I.
    Westhoff, Maartje
    Maurice, Yasmeen
    Eldstrom, Jodene
    Fedida, David
    BIOPHYSICAL JOURNAL, 2015, 108 (02) : 117A - 117A
  • [4] Unnatural amino acid photo-crosslinking of the IKs channel complex demonstrates a KCNE1:KCNQ1 stoichiometry of up to 4:4
    Murray, Christopher I.
    Westhoff, Maartje
    Eldstrom, Jodene
    Thompson, Emely
    Emes, Robert
    Fedida, David
    ELIFE, 2016, 5
  • [5] Insertion of Crosslinkable Amino Acids into the IKS Channel Complex Demonstrates a Variable KCNQ1:KCNE1 Stoichiometry of up to 4:4
    Westhoff, Maartje F. E.
    Murray, Christopher I.
    Thompson, Emely
    Emes, Robert
    Eldstrom, Jodene
    Fedida, David
    BIOPHYSICAL JOURNAL, 2016, 110 (03) : 107A - 107A
  • [6] Calcium/Calmodulin-Dependent Protein Kinase II Phosphorylation of KCNQ1 S484 Disrupts the Interaction Between KCNQ1 and KCNE1 Subunits
    Shugg, Tyler
    Dunn, Kenneth W.
    Cummins, Theodore R.
    Hudmon, Andy
    Overholser, Brain R.
    CIRCULATION, 2018, 138
  • [7] Steric hindrance between S4 and S5 of the KCNQ1/KCNE1 channel hampers pore opening
    Koichi Nakajo
    Yoshihiro Kubo
    Nature Communications, 5
  • [8] Steric hindrance between S4 and S5 of the KCNQ1/KCNE1 channel hampers pore opening
    Nakajo, Koichi
    Kubo, Yoshihiro
    NATURE COMMUNICATIONS, 2014, 5
  • [9] Characterization of binding site of closed-state KCNQ1 potassium channel by homology modeling, molecular docking, and pharmacophore identification
    Du, LP
    Li, MY
    Tsai, KC
    You, QD
    Xia, L
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 332 (03) : 677 - 687
  • [10] Pore- and state-dependent cadmium block of IKs channels formed with MinK-55C and wild-type KCNQ1 subunits
    Chen, HJ
    Sesti, F
    Goldstein, SAN
    BIOPHYSICAL JOURNAL, 2003, 84 (06) : 3679 - 3689
1