Influence of Electrospun Scaffolds Prepared From Distinct Polymers on Proliferation and Viability of Endothelial Cells

被引：0
|
作者：
Matveeva, V. G. [1 ]
Antonova, L. V. [1 ]
Velikanova, E. A. [1 ]
Sergeeva, E. A. [1 ]
Krivkina, E. O. [1 ]
Glushkova, T. V. [1 ]
Kudryavtseva, Yu. A. [1 ]
Barbarash, O. L. [1 ]
Barbarash, L. S. [1 ]
机构：
[1] Res Inst Complex Issues Cardiovasc Dis, Kemerovo 650002, Russia
来源：
INTERNATIONAL CONFERENCE ON ADVANCED MATERIALS WITH HIERARCHICAL STRUCTURE FOR NEW TECHNOLOGIES AND RELIABLE STRUCTURES 2015 | 2015年 / 1683卷
关键词：
D O I：
10.1063/1.4932834
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
We compared electrospun nonwoven scaffolds from polylactic acid (PLA), polycaprolactone (PCL), and polyhydroxybutyrate/valerate (PHBV)/polycaprolactone (PHBV/PCL). The surface of PHBV/PCL and PCL scaffolds was highly porous and consisted of randomly distributed fibers, whilst the surface of PLA scaffolds consisted of thin straight fibers, which located more sparsely, forming large pores. Culture of EA. hy 926 endothelial cells on these scaffolds during 7 days and further fluorescent microscopy demonstrated that the surface of PHBV/PCL scaffolds was most favorable for efficient adhesion, proliferation, and viability of endothelial cells. The lowest proliferation rate and cell viability were detected on PLA scaffolds. Therefore, PHBV/PCL electrospun nonwoven scaffolds demonstrated the best results regarding endothelial cell proliferation and viability as compared to PCL and PLA scaffolds.
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页数：4
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