A state-of-the-art review on the recent advances of niosomes as a targeted drug delivery system

被引:87
|
作者
Yasamineh, Saman [1 ]
Yasamineh, Pooneh [1 ]
Kalajahi, Hesam Ghafouri [2 ]
Gholizadeh, Omid [3 ]
Yekanipour, Zahra [4 ]
Afkhami, Hamed [5 ]
Eslami, Majid [6 ]
Kheirkhah, Amir Hossein [7 ]
Taghizadeh, Milad [8 ]
Yazdani, Yalda [9 ]
Dadashpour, Mehdi [10 ,11 ]
机构
[1] Islamic Azad Univ, Tabriz Branch, Young Researchers & Elite Club, Tabriz, Iran
[2] Uskudar Univ, Dept biotechnol, Istanbul, Turkey
[3] Tabriz Univ Med Sci, Fac Med Sci, Dept Virol, Tabriz, Iran
[4] Islamic Azad Univ, Dept Microbiol, Marand Branch, Marand, Iran
[5] Shahed Univ Med Sci, Fac Med, Dept Med Microbiol, Tehran, Iran
[6] Semnan Univ Med Sci, Sch Med, Dept Bacteriol & Virol, Semnan, Iran
[7] Shahid Sadoughi Univ Med Sci, Sch Med, Dept Med Genet, Yazd, Iran
[8] Tabriz Univ Med Sci, Fac Paramed, Dept Lab Sci, Tabriz, Iran
[9] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran
[10] Semnan Univ Med Sci, Fac Med, Dept Med Biotechnol, Semnan, Iran
[11] Semnan Univ Med Sci, Canc Res Ctr, Semnan, Iran
关键词
Niosomes; Nanoparticles; Drug delivery; Nonionic surfactants; Routes of administrations; IN-VITRO; HEATING METHOD; NONIONIC SURFACTANT; BOLA-SURFACTANT; NANO-NIOSOMES; CARRIER; GEL; FORMULATIONS; LIPOSOMES; COMBINATION;
D O I
10.1016/j.ijpharm.2022.121878
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The buildup of nonionic surfactants in the aqueous environment produces niosomes. The usage of niosomes is becoming increasingly frequent due to their sustainability, low cost of components and assembly, large-scale manufacture, and, finally, easy maintenance of the niosomes to the other. Because of their nonionic characteristics, niosomes play a critical role in medication delivery systems. Controlled release and targeted distribution of niosomes to treat cancer, infectious illnesses, and other disorders are one of their most important properties. Niosomes can also be injected by ocular and transdermal routes, which are less common than oral and parenteral administration. Using niosomes to manufacture biotechnology goods and novel vaccines is one of the most exciting research fields today. The molecular structure of niosomes, the physicochemical characteristics of nonionic surfactants in their formulation, the influence of external stimuli on niosomes, the many methods of niosomes administration, and their diverse therapeutic qualities are all explored in this study.
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页数:21
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