Evaluation of the developmental toxicity of crocetin on Xenopus

被引：46
|
作者：
Martin, G
Goh, E
Neff, AW
机构：
[1] Indiana Univ, Coll Arts & Sci, Bloomington, IN 47405 USA
[2] Indiana Univ, Sch Med, Med Sci Program, Bloomington, IN 47405 USA
来源：
FOOD AND CHEMICAL TOXICOLOGY | 2002年 / 40卷 / 07期
关键词：
Xenopus laevis; crocetin; retinoic acid; teratogenesis;
D O I：
10.1016/S0278-6915(02)00040-6
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Crocetin, a carotenoid isolated from the spice saffron, has been found to be effective in treating certain types of cancer treatable with all-trans retinoic acid (ATRA). ATRA, however, is a potent teratogen, and the possibility that crocetin may also be a teratogen becomes an important medical issue. The teratogenic potential of crocetin and ATRA were evaluated in frog (Xenopus) embryos. The data show that crocetin is a teratogen, but far less potent than ATRA. This suggests that crocetin may be a safer alternative to treat ATRA-sensitive cancers in women of childbearing age. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：959 / 964
页数：6
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