Efficacy and safety of spironolactone for the treatment of patients with acute heart failure A protocol for systematic review

Background: This study will investigate the efficacy and safety of spironolactone for the treatment of acute heart failure (AHF). Methods: The following electronic databases will be retrieved in PUBMED, EMBASE, Cochrane Library, Web of Science, CINAHL, CBM, CNKI, and VIP database from inception through present. Two researchers will independently screen and assess the obtained literatures and extract outcome data. All study methodological quality will be assessed using Cochrane risk of bias tool, and all statistical analysis will be performed by RevMan 5.3 software. Additionally, we will undertake a narrative synthesis if it is possible. Results: This study will sum-marize most recent evidence to investigate the efficacy and safety of spironolactone for the treatment of AHF. Conclusion: This study will seek to assess the efficacy and safety of spironolactone for treating AHF. Systematic review registration: INPLASY202070053.