The Y-family DNA polymerase κ (pol κ) functions in mammalian nucleotide-excision repair

被引：168
|
作者：
Ogi, Tomoo [1 ]
Lehmann, Alan R. [1 ]
机构：
[1] Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England
来源：
NATURE CELL BIOLOGY | 2006年 / 8卷 / 06期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1038/ncb1417
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
DNA polymerase. (pol kappa) is a member of the Y-family of DNA polymerases that are thought to function in translesion synthesis (TLS) past different types of DNA damage. Here, we show that pol kappa-deficient mouse cells have substantially reduced (but not absent) levels of nucleotide excision repair (NER) of UV damage, as measured by several methods. Our results provide evidence for an unexpected role for pol. in mammalian NER.
引用
收藏
页码：640 / 642
页数：3
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