Water exchange in lanthanide complexes for MRI applications. Lessons learned over the last 25 years

被引:37
|
作者
Caravan, Peter [3 ,4 ]
Esteban-Gomez, David [1 ,2 ]
Rodriguez-Rodriguez, Aurora [1 ,2 ]
Platas-Iglesias, Carlos [1 ,2 ,3 ,4 ]
机构
[1] Univ A Coruna, CICA, Campus Zapateira Rua Fraga 10, La Coruna 15008, Spain
[2] Univ A Coruna, Dept Quim, Campus Zapateira Rua Fraga 10, La Coruna 15008, Spain
[3] Harvard Med Sch, Massachusetts Gen Hosp, Inst Innovat Imaging, 149 13th St,Suite 2301, Charlestown, MA 02129 USA
[4] Harvard Med Sch, Massachusetts Gen Hosp, AA Martinos Ctr Biomed Imaging, 149 13th St,Suite 2301, Charlestown, MA 02129 USA
关键词
IMAGING CONTRAST AGENTS; DOTA-TETRAAMIDE COMPLEXES; X-RAY CRYSTAL; O-17; NMR; AQUEOUS-SOLUTION; PARACEST AGENTS; GADOLINIUM(III) COMPLEXES; VARIABLE-TEMPERATURE; KINETIC INERTNESS; GD(III) COMPLEXES;
D O I
10.1039/c9dt01948k
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The water exchange rates of water molecules coordinated to the metal ion in lanthanide complexes have been profusely investigated during the last 25 years, especially in the case of Gd3+ and Eu3+ complexes. This is mainly related to the important application of some Gd3+ complexes as contrast agents in magnetic resonance imaging (MRI), and the intensive investigation of Eu3+ complexes as contrast agent candidates providing contrast through the chemical exchange saturation transfer mechanism (CEST). Both applications require a fine tunning of the exchange rate of the coordinated water molecule to yield optimal response. Herein we review the progress made in this field to control water exchange in a rational way through ligand design, providing relationships between the observed trends, the structures of the complexes and the mechanisms responsible for the water exchange reaction.
引用
收藏
页码:11161 / 11180
页数:20
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